Drug interactions
Rimegepant + Sotorasib
Severity: Moderate
Rimegepant and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inducer in vitro, which could in theory lower rimegepant exposure. The significance for migraine efficacy is uncertain.
What this interaction means in plain words
Rimegepant and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may induce P-gp and CYP3A4, potentially increasing rimegepant efflux and metabolism; the effect is not well characterized.
What to do
Monitor for reduced migraine response, and consider an alternative agent if rimegepant becomes ineffective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Rimegepant with Sotorasib?
MediHelp rates the interaction as moderate. Rimegepant and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inducer in vitro, which could in theory lower rimegepant exposure. The significance for migraine efficacy is uncertain.
How serious is the interaction between Rimegepant and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine response, and consider an alternative agent if rimegepant becomes ineffective.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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