Drug interactions
Rimegepant + Suvorexant
Severity: Minor
Rimegepant and Suvorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is a weak P-gp inhibitor and might slightly increase rimegepant exposure. The clinical impact is probably small.
What this interaction means in plain words
Rimegepant and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rimegepant belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Suvorexant may weakly inhibit intestinal P-gp efflux of rimegepant.
What to do
No routine adjustment is needed; observe for increased adverse effects and avoid repeat rimegepant dosing within 48 hours.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rimegepant
Other interactions of Suvorexant
Frequently asked questions
Can I take Rimegepant with Suvorexant?
MediHelp rates the interaction as minor. Rimegepant and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Suvorexant is a weak P-gp inhibitor and might slightly increase rimegepant exposure. The clinical impact is probably small.
How serious is the interaction between Rimegepant and Suvorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; observe for increased adverse effects and avoid repeat rimegepant dosing within 48 hours.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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