Drug interactions
Riociguat + Roflumilast
Severity: Minor
Riociguat and Roflumilast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat is contraindicated with PDE inhibitors that act on the cGMP pathway, and roflumilast is a PDE4 inhibitor acting mainly on cAMP, so a clinically significant interaction is not well established. Additive hypotension is theoretical.
What this interaction means in plain words
Riociguat and Roflumilast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Riociguat belongs to Cardiovascular; Roflumilast belongs to Respiratory.
Why it happens
Theoretical additive vasodilation; PDE4 inhibition does not directly potentiate the cGMP pathway.
What to do
Monitor blood pressure when starting or changing either drug. No dose adjustment is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Roflumilast
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Riociguat with Roflumilast?
MediHelp rates the interaction as minor. Riociguat and Roflumilast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Riociguat is contraindicated with PDE inhibitors that act on the cGMP pathway, and roflumilast is a PDE4 inhibitor acting mainly on cAMP, so a clinically significant interaction is not well established. Additive hypotension is theoretical.
How serious is the interaction between Riociguat and Roflumilast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or changing either drug. No dose adjustment is routinely needed.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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