Drug interactions
Riociguat + Simvastatin
Severity: Minor
Riociguat and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Simvastatin is not a strong CYP inhibitor, so no significant rise in riociguat exposure is expected. Statins have been given with riociguat in clinical studies without a meaningful pharmacokinetic effect.
What this interaction means in plain words
Riociguat and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Riociguat belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
No clinically relevant mechanism is established; simvastatin is a weak inhibitor of riociguat metabolic pathways at most.
What to do
No dose adjustment needed; monitor blood pressure as usual during riociguat therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Riociguat with Simvastatin?
MediHelp rates the interaction as minor. Riociguat and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Simvastatin is not a strong CYP inhibitor, so no significant rise in riociguat exposure is expected. Statins have been given with riociguat in clinical studies without a meaningful pharmacokinetic effect.
How serious is the interaction between Riociguat and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; monitor blood pressure as usual during riociguat therapy.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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