Drug interactions
Risperidone + Sufentanil sl
Severity: Major
Risperidone and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil is an opioid, and combining it with risperidone can cause additive sedation, hypotension and respiratory depression. Severe cases may progress to coma or death.
What this interaction means in plain words
Risperidone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression and additive hypotensive effects (pharmacodynamic synergism).
What to do
Reserve the combination for patients without alternatives, use the lowest effective doses for the shortest duration, and monitor for sedation, respiratory depression and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Sufentanil sl?
MediHelp rates the interaction as major. Risperidone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil is an opioid, and combining it with risperidone can cause additive sedation, hypotension and respiratory depression. Severe cases may progress to coma or death.
How serious is the interaction between Risperidone and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without alternatives, use the lowest effective doses for the shortest duration, and monitor for sedation, respiratory depression and blood pressure.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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