Drug interactions
Risperidone + Triazolam
Severity: Moderate
Risperidone and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, so combined use can produce excessive drowsiness, impaired psychomotor performance and orthostatic hypotension. Older patients are at greater risk of falls.
What this interaction means in plain words
Risperidone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and antipsychotic receptor blockade.
What to do
Use the lowest effective triazolam dose and monitor for oversedation and hypotension; warn about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Triazolam?
MediHelp rates the interaction as moderate. Risperidone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, so combined use can produce excessive drowsiness, impaired psychomotor performance and orthostatic hypotension. Older patients are at greater risk of falls.
How serious is the interaction between Risperidone and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triazolam dose and monitor for oversedation and hypotension; warn about driving.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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