Drug interactions
Risperidone + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Risperidone and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol can have cardiovascular effects including tachycardia and QT prolongation, and risperidone also prolongs QTc. Systemic exposure from inhalation is low, so the effect is usually small but could matter in patients with cardiac risk factors.
What this interaction means in plain words
Risperidone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and beta-adrenergic cardiovascular effects.
What to do
Monitor heart rate and ECG in patients with cardiac disease, hypokalemia or other QT risk factors, and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Risperidone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol can have cardiovascular effects including tachycardia and QT prolongation, and risperidone also prolongs QTc. Systemic exposure from inhalation is low, so the effect is usually small but could matter in patients with cardiac risk factors.
How serious is the interaction between Risperidone and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac disease, hypokalemia or other QT risk factors, and correct electrolytes.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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