Drug interactions
Risperidone + Yohimbine
Severity: Moderate
Risperidone and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that can cause anxiety, agitation and increased blood pressure, which may counter the calming effects of risperidone. Yohimbine may also worsen psychosis symptoms, and the net effect on sedation is unpredictable.
What this interaction means in plain words
Risperidone and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects: yohimbine increases noradrenergic activity while risperidone blocks dopaminergic, serotonergic and alpha-adrenergic receptors.
What to do
Avoid yohimbine in patients with psychotic disorders where possible, and monitor mental state and blood pressure if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Yohimbine?
MediHelp rates the interaction as moderate. Risperidone and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that can cause anxiety, agitation and increased blood pressure, which may counter the calming effects of risperidone. Yohimbine may also worsen psychosis symptoms, and the net effect on sedation is unpredictable.
How serious is the interaction between Risperidone and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine in patients with psychotic disorders where possible, and monitor mental state and blood pressure if used.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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