Drug interactions
Ritlecitinib + Ropinirole
Severity: Moderate
Ritlecitinib and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP1A2 and may raise ropinirole exposure, since ropinirole is cleared mainly by CYP1A2. This may increase somnolence, nausea, hypotension and other dopaminergic effects.
What this interaction means in plain words
Ritlecitinib and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritlecitinib belongs to Oncology; Ropinirole belongs to Central Nervous System.
Why it happens
Ritlecitinib inhibits CYP1A2-mediated metabolism of ropinirole.
What to do
Monitor for ropinirole adverse effects and reduce the dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Ritlecitinib with Ropinirole?
MediHelp rates the interaction as moderate. Ritlecitinib and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP1A2 and may raise ropinirole exposure, since ropinirole is cleared mainly by CYP1A2. This may increase somnolence, nausea, hypotension and other dopaminergic effects.
How serious is the interaction between Ritlecitinib and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ropinirole adverse effects and reduce the dose if they appear.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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