Drug interactions
Ritonavir + Roflumilast
Severity: Moderate
Ritonavir and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 inhibitor and can increase roflumilast exposure. This may increase adverse effects such as diarrhea, nausea, weight loss, insomnia and psychiatric events.
What this interaction means in plain words
Ritonavir and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Roflumilast belongs to Respiratory.
Why it happens
Ritonavir inhibits CYP3A4, reducing roflumilast metabolism.
What to do
Monitor for roflumilast adverse effects, particularly weight loss and neuropsychiatric symptoms, and consider interrupting roflumilast during prolonged ritonavir use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Roflumilast?
MediHelp rates the interaction as moderate. Ritonavir and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is a strong CYP3A4 inhibitor and can increase roflumilast exposure. This may increase adverse effects such as diarrhea, nausea, weight loss, insomnia and psychiatric events.
How serious is the interaction between Ritonavir and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects, particularly weight loss and neuropsychiatric symptoms, and consider interrupting roflumilast during prolonged ritonavir use.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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