Drug interactions
Ritonavir + Saxagliptin-metformin
Severity: Moderate
Ritonavir and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 inhibitor that raises saxagliptin levels. Protease inhibitors may also cause insulin resistance and hyperglycemia, reducing the effect of metformin.
What this interaction means in plain words
Ritonavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Saxagliptin-metformin belongs to Endocrine.
Why it happens
CYP3A4 inhibition increases saxagliptin exposure, and ritonavir induces insulin resistance.
What to do
Limit saxagliptin to 2.5 mg daily and monitor blood glucose, adjusting antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Ritonavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is a strong CYP3A4 inhibitor that raises saxagliptin levels. Protease inhibitors may also cause insulin resistance and hyperglycemia, reducing the effect of metformin.
How serious is the interaction between Ritonavir and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg daily and monitor blood glucose, adjusting antidiabetic therapy as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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