Drug interactions
Ritonavir + Sitagliptin
Severity: Moderate
Ritonavir and Sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can induce insulin resistance and hyperglycemia, potentially offsetting the effect of sitagliptin. Ritonavir may also inhibit P-glycoprotein, but this is unlikely to matter clinically.
What this interaction means in plain words
Ritonavir and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism via protease inhibitor-related insulin resistance; minor P-gp inhibition.
What to do
Monitor glucose and HbA1c after starting or changing ritonavir-containing regimens. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Sitagliptin?
MediHelp rates the interaction as moderate. Ritonavir and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir can induce insulin resistance and hyperglycemia, potentially offsetting the effect of sitagliptin. Ritonavir may also inhibit P-glycoprotein, but this is unlikely to matter clinically.
How serious is the interaction between Ritonavir and Sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting or changing ritonavir-containing regimens. Adjust antidiabetic therapy as needed.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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