Drug interactions
Ritonavir + Tolazamide
Severity: Moderate
Ritonavir and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can alter glucose control in patients taking tolazamide. Protease inhibitors are associated with insulin resistance and hyperglycemia, and ritonavir's enzyme effects may change sulfonylurea exposure in either direction.
What this interaction means in plain words
Ritonavir and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Tolazamide belongs to Endocrine.
Why it happens
Ritonavir causes insulin resistance and has mixed inhibitory and inductive effects on hepatic enzymes, so the net effect on tolazamide is unpredictable.
What to do
Monitor blood glucose when ritonavir is started, changed or stopped. Adjust the tolazamide dose or add other antidiabetic therapy according to the readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Tolazamide?
MediHelp rates the interaction as moderate. Ritonavir and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir can alter glucose control in patients taking tolazamide. Protease inhibitors are associated with insulin resistance and hyperglycemia, and ritonavir's enzyme effects may change sulfonylurea exposure in either direction.
How serious is the interaction between Ritonavir and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ritonavir is started, changed or stopped. Adjust the tolazamide dose or add other antidiabetic therapy according to the readings.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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