Drug interactions
Ritonavir + Umeclidinium-vilanterol
Severity: Moderate
Ritonavir and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a potent CYP3A4 inhibitor and can substantially increase systemic vilanterol exposure. This may result in tachycardia, QT prolongation and hypokalemia.
What this interaction means in plain words
Ritonavir and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Ritonavir potently inhibits CYP3A4, reducing vilanterol clearance.
What to do
Monitor heart rate, ECG and potassium, and use the lowest effective dose; consider an alternative bronchodilator if cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ritonavir and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Ritonavir and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is a potent CYP3A4 inhibitor and can substantially increase systemic vilanterol exposure. This may result in tachycardia, QT prolongation and hypokalemia.
How serious is the interaction between Ritonavir and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium, and use the lowest effective dose; consider an alternative bronchodilator if cardiovascular effects occur.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
