Drug interactions
Ritonavir + Zidovudine
Severity: Minor
Ritonavir and Zidovudine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are used in HIV therapy, and immune reconstitution inflammatory syndrome may occur after effective treatment starts. Ritonavir may also modestly lower zidovudine levels, which is usually not clinically important.
What this interaction means in plain words
Ritonavir and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ritonavir belongs to Anti Virals; Zidovudine belongs to Anti Virals.
Why it happens
Immune reconstitution results from immune recovery; ritonavir may induce zidovudine glucuronidation.
What to do
Monitor for new inflammatory or opportunistic infection symptoms after starting therapy. No dose adjustment is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Zidovudine?
MediHelp rates the interaction as minor. Ritonavir and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are used in HIV therapy, and immune reconstitution inflammatory syndrome may occur after effective treatment starts. Ritonavir may also modestly lower zidovudine levels, which is usually not clinically important.
How serious is the interaction between Ritonavir and Zidovudine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for new inflammatory or opportunistic infection symptoms after starting therapy. No dose adjustment is required.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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