Drug interactions
Rituximab + Trastuzumab deruxtecan
Severity: Moderate
Rituximab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia and increase infection susceptibility, so combined use may add to myelosuppression. Trastuzumab deruxtecan also carries a risk of interstitial lung disease that complicates infection assessment.
What this interaction means in plain words
Rituximab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rituximab belongs to Musculoskeletal; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression from the topoisomerase I inhibitor payload and B-cell depletion.
What to do
Monitor complete blood counts and for signs of infection and febrile neutropenia. Investigate new respiratory symptoms promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Rituximab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Rituximab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neutropenia and increase infection susceptibility, so combined use may add to myelosuppression. Trastuzumab deruxtecan also carries a risk of interstitial lung disease that complicates infection assessment.
How serious is the interaction between Rituximab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for signs of infection and febrile neutropenia. Investigate new respiratory symptoms promptly.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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