Drug interactions
Rivaroxaban + Tirofiban
Severity: Major
Rivaroxaban and Tirofiban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tirofiban blocks platelet glycoprotein IIb/IIIa receptors, a strong antiplatelet effect that when added to rivaroxaban sharply increases bleeding risk. It is given in acute settings, so overlap should be managed deliberately.
What this interaction means in plain words
Rivaroxaban and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rivaroxaban belongs to Cardiovascular; Tirofiban belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect from GP IIb/IIIa inhibition together with factor Xa inhibition.
What to do
Avoid overlap where possible, for example by timing rivaroxaban after the tirofiban infusion ends. If both are given, monitor closely for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Tirofiban
Frequently asked questions
Can I take Rivaroxaban with Tirofiban?
MediHelp rates the interaction as major. Rivaroxaban and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tirofiban blocks platelet glycoprotein IIb/IIIa receptors, a strong antiplatelet effect that when added to rivaroxaban sharply increases bleeding risk. It is given in acute settings, so overlap should be managed deliberately.
How serious is the interaction between Rivaroxaban and Tirofiban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid overlap where possible, for example by timing rivaroxaban after the tirofiban infusion ends. If both are given, monitor closely for bleeding and hemoglobin.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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