Drug interactions
Rivastigmine + Sotalol
Severity: Moderate
Rivastigmine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rivastigmine, a cholinesterase inhibitor, increases vagal tone and can cause bradycardia, and sotalol slows heart rate through beta-blockade. Together they may cause marked bradycardia, heart block or syncope.
What this interaction means in plain words
Rivastigmine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rivastigmine belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic effects from cholinergic stimulation and beta-adrenergic blockade.
What to do
Monitor heart rate and watch for dizziness or syncope when starting or increasing either drug. Reduce the dose or stop rivastigmine if symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Rivastigmine
Frequently asked questions
Can I take Rivastigmine with Sotalol?
MediHelp rates the interaction as moderate. Rivastigmine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rivastigmine, a cholinesterase inhibitor, increases vagal tone and can cause bradycardia, and sotalol slows heart rate through beta-blockade. Together they may cause marked bradycardia, heart block or syncope.
How serious is the interaction between Rivastigmine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and watch for dizziness or syncope when starting or increasing either drug. Reduce the dose or stop rivastigmine if symptomatic bradycardia occurs.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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