Drug interactions
Rivastigmine + Trazodone
Severity: Minor
Rivastigmine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rivastigmine enhances cholinergic transmission, while trazodone has only weak anticholinergic activity, so meaningful opposition is unlikely. Clinical consequences are not well documented.
What this interaction means in plain words
Rivastigmine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rivastigmine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Theoretical pharmacodynamic opposition between cholinesterase inhibition and weak anticholinergic effects of trazodone.
What to do
No routine change is needed; monitor cognition and watch for sedation or bradycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Rivastigmine
Frequently asked questions
Can I take Rivastigmine with Trazodone?
MediHelp rates the interaction as minor. Rivastigmine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rivastigmine enhances cholinergic transmission, while trazodone has only weak anticholinergic activity, so meaningful opposition is unlikely. Clinical consequences are not well documented.
How serious is the interaction between Rivastigmine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor cognition and watch for sedation or bradycardia.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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