Drug interactions
Rizatriptan + Same
Severity: Minor
Rizatriptan and Same: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) has been associated with increased serotonergic activity and rare serotonin syndrome in combination with serotonergic drugs. With a triptan the risk is theoretical.
What this interaction means in plain words
Rizatriptan and Same have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive serotonergic effects; the mechanism is not firmly established.
What to do
Ask about supplement use and counsel on serotonin syndrome symptoms. Stop SAMe if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Rizatriptan with Same?
MediHelp rates the interaction as minor. Rizatriptan and Same have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. S-adenosylmethionine (SAMe) has been associated with increased serotonergic activity and rare serotonin syndrome in combination with serotonergic drugs. With a triptan the risk is theoretical.
How serious is the interaction between Rizatriptan and Same?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about supplement use and counsel on serotonin syndrome symptoms. Stop SAMe if they appear.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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