Drug interactions
Rizatriptan + Selegiline transdermal
Severity: Contraindicated
Rizatriptan and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rizatriptan is metabolized mainly by monoamine oxidase A, and MAO inhibition raises its exposure substantially; rizatriptan labeling contraindicates use with MAOIs or within two weeks of stopping them. Transdermal selegiline at antidepressant doses inhibits MAO nonselectively, so the combination adds a risk of serotonin syndrome to higher triptan levels.
What this interaction means in plain words
Rizatriptan and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of MAO-A reduces rizatriptan metabolism and adds to serotonergic effects.
What to do
Avoid the combination and do not give rizatriptan within two weeks of stopping selegiline. Use a non-triptan acute migraine treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rizatriptan and Selegiline transdermal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Rizatriptan with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Rizatriptan and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rizatriptan is metabolized mainly by monoamine oxidase A, and MAO inhibition raises its exposure substantially; rizatriptan labeling contraindicates use with MAOIs or within two weeks of stopping them. Transdermal selegiline at antidepressant doses inhibits MAO nonselectively, so the combination adds a risk of serotonin syndrome to higher triptan levels.
How serious is the interaction between Rizatriptan and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and do not give rizatriptan within two weeks of stopping selegiline. Use a non-triptan acute migraine treatment.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
