Drug interactions
Rizatriptan + Sufentanil sl
Severity: Moderate
Rizatriptan and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid, and opioids have rare associations with serotonin syndrome when combined with triptans. Symptoms include agitation, tremor, hyperthermia and autonomic instability. The risk is low but should be recognized.
What this interaction means in plain words
Rizatriptan and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from the opioid and the 5-HT1B/1D agonist.
What to do
Monitor for serotonin syndrome, especially at initiation and dose increases. Stop one or both agents if signs develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Rizatriptan with Sufentanil sl?
MediHelp rates the interaction as moderate. Rizatriptan and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a potent opioid, and opioids have rare associations with serotonin syndrome when combined with triptans. Symptoms include agitation, tremor, hyperthermia and autonomic instability. The risk is low but should be recognized.
How serious is the interaction between Rizatriptan and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, especially at initiation and dose increases. Stop one or both agents if signs develop.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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