Drug interactions
Rizatriptan + Venlafaxine
Severity: Moderate
Rizatriptan and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic transmission, so serotonin syndrome is possible though uncommon. The combination is often used in patients with migraine and depression.
What this interaction means in plain words
Rizatriptan and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rizatriptan belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from serotonin-norepinephrine reuptake inhibition and 5-HT1B/1D agonism.
What to do
Counsel patients to report agitation, tremor, sweating, diarrhea or fever promptly. Use the lowest effective triptan dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Rizatriptan with Venlafaxine?
MediHelp rates the interaction as moderate. Rizatriptan and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic transmission, so serotonin syndrome is possible though uncommon. The combination is often used in patients with migraine and depression.
How serious is the interaction between Rizatriptan and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, sweating, diarrhea or fever promptly. Use the lowest effective triptan dose.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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