Drug interactions
Roflumilast + Secobarbital
Severity: Moderate
Roflumilast and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and CYP1A2 and may lower roflumilast exposure, as seen with strong inducers like rifampicin. Efficacy may be reduced.
What this interaction means in plain words
Roflumilast and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Roflumilast belongs to Respiratory; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-mediated induction of CYP3A4 and CYP1A2 increases roflumilast metabolism.
What to do
Monitor COPD control and exacerbation frequency. Consider an alternative to roflumilast if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Roflumilast with Secobarbital?
MediHelp rates the interaction as moderate. Roflumilast and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and CYP1A2 and may lower roflumilast exposure, as seen with strong inducers like rifampicin. Efficacy may be reduced.
How serious is the interaction between Roflumilast and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor COPD control and exacerbation frequency. Consider an alternative to roflumilast if response declines.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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