Drug interactions
Romidepsin + Sevoflurane
Severity: Major
Romidepsin and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause ECG changes including QT prolongation, and sevoflurane can add to this effect. The combination may increase risk of ventricular arrhythmias.
What this interaction means in plain words
Romidepsin and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Check a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Romidepsin with Sevoflurane?
MediHelp rates the interaction as major. Romidepsin and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Romidepsin can cause ECG changes including QT prolongation, and sevoflurane can add to this effect. The combination may increase risk of ventricular arrhythmias.
How serious is the interaction between Romidepsin and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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