Drug interactions
Romidepsin + Trazodone
Severity: Moderate
Romidepsin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is a P-glycoprotein and CYP3A4 substrate that can prolong QT, and trazodone has a known QT liability. Evidence for any transporter effect of trazodone is weak, but additive QT risk is plausible.
What this interaction means in plain words
Romidepsin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation; a P-glycoprotein effect of trazodone is not well established.
What to do
Check baseline ECG and correct potassium and magnesium before and during romidepsin cycles. Monitor the QTc if both drugs are continued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Romidepsin with Trazodone?
MediHelp rates the interaction as moderate. Romidepsin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin is a P-glycoprotein and CYP3A4 substrate that can prolong QT, and trazodone has a known QT liability. Evidence for any transporter effect of trazodone is weak, but additive QT risk is plausible.
How serious is the interaction between Romidepsin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before and during romidepsin cycles. Monitor the QTc if both drugs are continued.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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