Drug interactions
Rosiglitazone + Somapacitan
Severity: Moderate
Rosiglitazone and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity and can raise blood glucose, working against the glucose-lowering effect of rosiglitazone. Glycemic control may worsen after somapacitan is started, especially at higher doses or in patients with diabetes or glucose intolerance.
What this interaction means in plain words
Rosiglitazone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosiglitazone belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance, opposing the insulin-sensitizing action of rosiglitazone.
What to do
Monitor blood glucose and HbA1c after starting or changing the dose of somapacitan. Adjust the rosiglitazone dose or other antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Rosiglitazone with Somapacitan?
MediHelp rates the interaction as moderate. Rosiglitazone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and can raise blood glucose, working against the glucose-lowering effect of rosiglitazone. Glycemic control may worsen after somapacitan is started, especially at higher doses or in patients with diabetes or glucose intolerance.
How serious is the interaction between Rosiglitazone and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the dose of somapacitan. Adjust the rosiglitazone dose or other antidiabetic therapy as required.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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