Drug interactions
Rosiglitazone + Somatrogon
Severity: Moderate
Rosiglitazone and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a long-acting growth hormone, can reduce insulin sensitivity and raise glucose levels. This may weaken the glycemic effect of rosiglitazone in patients with diabetes.
What this interaction means in plain words
Rosiglitazone and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosiglitazone belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance, opposing the insulin-sensitizing action of rosiglitazone.
What to do
Monitor blood glucose and HbA1c when somatrogon is started or its dose is changed. Increase the rosiglitazone dose or add other antidiabetic treatment if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rosiglitazone and Somatrogon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Rosiglitazone with Somatrogon?
MediHelp rates the interaction as moderate. Rosiglitazone and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a long-acting growth hormone, can reduce insulin sensitivity and raise glucose levels. This may weaken the glycemic effect of rosiglitazone in patients with diabetes.
How serious is the interaction between Rosiglitazone and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when somatrogon is started or its dose is changed. Increase the rosiglitazone dose or add other antidiabetic treatment if control worsens.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
