Drug interactions
Rosiglitazone + Triamcinolone
Severity: Moderate
Rosiglitazone and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose by increasing hepatic gluconeogenesis and insulin resistance, which can offset the glucose-lowering effect of rosiglitazone. The effect is greater with repeated or high-dose injections and may be seen for days to weeks after a depot injection.
What this interaction means in plain words
Rosiglitazone and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosiglitazone belongs to Endocrine; Triamcinolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoid-induced insulin resistance and hyperglycemia oppose thiazolidinedione insulin sensitization.
What to do
Monitor blood glucose more often for several weeks after triamcinolone injection and adjust antidiabetic therapy if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Rosiglitazone with Triamcinolone?
MediHelp rates the interaction as moderate. Rosiglitazone and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose by increasing hepatic gluconeogenesis and insulin resistance, which can offset the glucose-lowering effect of rosiglitazone. The effect is greater with repeated or high-dose injections and may be seen for days to weeks after a depot injection.
How serious is the interaction between Rosiglitazone and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often for several weeks after triamcinolone injection and adjust antidiabetic therapy if hyperglycemia develops.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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