Drug interactions
Rosuvastatin + Selpercatinib
Severity: Moderate
Rosuvastatin and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can raise rosuvastatin exposure, increasing the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Rosuvastatin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Selpercatinib belongs to Oncology.
Why it happens
Selpercatinib inhibits BCRP, increasing rosuvastatin absorption and reducing its efflux.
What to do
Monitor for muscle pain or weakness and consider a lower rosuvastatin dose or check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selpercatinib
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rosuvastatin with Selpercatinib?
MediHelp rates the interaction as moderate. Rosuvastatin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can raise rosuvastatin exposure, increasing the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Rosuvastatin and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain or weakness and consider a lower rosuvastatin dose or check CK if symptoms occur.
What other medicines interact with Selpercatinib?
MediHelp also lists interactions of Selpercatinib with, for example, Amiodarone, Amisulpride, Amitriptyline. The full list is on the Selpercatinib page.
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