Drug interactions
Rosuvastatin + Sofosbuvir-velpatasvir
Severity: Major
Rosuvastatin and Sofosbuvir-velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir substantially increases rosuvastatin exposure, raising the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Rosuvastatin and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rosuvastatin belongs to Cardiovascular; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits BCRP and OATP1B1/1B3.
What to do
If coadministered, keep rosuvastatin at 10 mg daily or less and monitor for muscle symptoms and CK.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rosuvastatin with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as major. Rosuvastatin and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir substantially increases rosuvastatin exposure, raising the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Rosuvastatin and Sofosbuvir-velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministered, keep rosuvastatin at 10 mg daily or less and monitor for muscle symptoms and CK.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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