Drug interactions
Rotavirus oral vaccine live + Vedolizumab
Severity: Moderate
Rotavirus oral vaccine live and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral rotavirus vaccine is a live attenuated vaccine that replicates in the gut, the site targeted by vedolizumab. Gut-selective immune modulation could theoretically reduce the response or allow prolonged vaccine-virus replication.
What this interaction means in plain words
Rotavirus oral vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Vedolizumab blocks α4β7 integrin-mediated lymphocyte homing to the gut, theoretically impairing local control of live vaccine virus.
What to do
Immunize infants before maternal vedolizumab exposure where possible. Otherwise weigh benefit against risk and review the infant's exposure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Rotavirus oral vaccine live with Vedolizumab?
MediHelp rates the interaction as moderate. Rotavirus oral vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral rotavirus vaccine is a live attenuated vaccine that replicates in the gut, the site targeted by vedolizumab. Gut-selective immune modulation could theoretically reduce the response or allow prolonged vaccine-virus replication.
How serious is the interaction between Rotavirus oral vaccine live and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Immunize infants before maternal vedolizumab exposure where possible. Otherwise weigh benefit against risk and review the infant's exposure history.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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