Drug interactions
Rozanolixizumab + Ustekinumab
Severity: Moderate
Rozanolixizumab and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rozanolixizumab blocks the neonatal Fc receptor and speeds IgG catabolism. Ustekinumab is an IgG1 antibody, so its exposure and effect may fall.
What this interaction means in plain words
Rozanolixizumab and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rozanolixizumab belongs to Miscellaneous; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
FcRn blockade reduces IgG recycling and may increase clearance of ustekinumab.
What to do
Monitor disease control of the condition treated with ustekinumab. Consider alternative therapy if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Rozanolixizumab
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Bevacizumab + Rozanolixizumab Moderate
Frequently asked questions
Can I take Rozanolixizumab with Ustekinumab?
MediHelp rates the interaction as moderate. Rozanolixizumab and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor and speeds IgG catabolism. Ustekinumab is an IgG1 antibody, so its exposure and effect may fall.
How serious is the interaction between Rozanolixizumab and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease control of the condition treated with ustekinumab. Consider alternative therapy if response is lost.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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