Drug interactions
Rubella vaccine + Vedolizumab
Severity: Moderate
Rubella vaccine and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rubella vaccine is a live attenuated vaccine. Vedolizumab labeling advises avoiding live vaccines unless benefit outweighs risk, owing to possible reduced response or vaccine-virus infection, though systemic immunosuppression is limited.
What this interaction means in plain words
Rubella vaccine and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical reduction in immune control of live attenuated virus by vedolizumab, which acts selectively on the gut.
What to do
Give rubella vaccination before starting vedolizumab when feasible. If already on therapy, vaccinate only when benefit outweighs risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Rubella vaccine with Vedolizumab?
MediHelp rates the interaction as moderate. Rubella vaccine and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rubella vaccine is a live attenuated vaccine. Vedolizumab labeling advises avoiding live vaccines unless benefit outweighs risk, owing to possible reduced response or vaccine-virus infection, though systemic immunosuppression is limited.
How serious is the interaction between Rubella vaccine and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give rubella vaccination before starting vedolizumab when feasible. If already on therapy, vaccinate only when benefit outweighs risk.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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