Drug interactions
Rucaparib + Tofacitinib
Severity: Moderate
Rucaparib and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C19 and CYP3A4 and may modestly increase tofacitinib levels. This may raise the risk of tofacitinib adverse effects.
What this interaction means in plain words
Rucaparib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Rucaparib inhibits CYP2C19 and CYP3A4, which are involved in tofacitinib metabolism.
What to do
Monitor for infection, cytopenias and other tofacitinib adverse effects. Reduce the tofacitinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tofacitinib?
MediHelp rates the interaction as moderate. Rucaparib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C19 and CYP3A4 and may modestly increase tofacitinib levels. This may raise the risk of tofacitinib adverse effects.
How serious is the interaction between Rucaparib and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection, cytopenias and other tofacitinib adverse effects. Reduce the tofacitinib dose if toxicity occurs.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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