Drug interactions
Rucaparib + Ulipristal
Severity: Minor
Rucaparib and Ulipristal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak CYP3A4 inhibitor and may modestly increase ulipristal exposure. Ulipristal is given as a single dose, so the clinical impact is likely small.
What this interaction means in plain words
Rucaparib and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4-mediated ulipristal metabolism by rucaparib.
What to do
No dose change is generally needed for a single ulipristal dose. Watch for increased adverse effects such as headache or nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Ulipristal?
MediHelp rates the interaction as minor. Rucaparib and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak CYP3A4 inhibitor and may modestly increase ulipristal exposure. Ulipristal is given as a single dose, so the clinical impact is likely small.
How serious is the interaction between Rucaparib and Ulipristal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed for a single ulipristal dose. Watch for increased adverse effects such as headache or nausea.
What other medicines interact with Rucaparib?
MediHelp also lists interactions of Rucaparib with, for example, Cisapride, Ergotamine, Pimozide. The full list is on the Rucaparib page.
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