Drug interactions
Rucaparib + Venlafaxine
Severity: Minor
Rucaparib and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and CYP2D6, and venlafaxine is metabolised mainly by CYP2D6 with a minor CYP3A4 contribution. A modest rise in venlafaxine exposure is possible but is unlikely to be clinically important.
What this interaction means in plain words
Rucaparib and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6/CYP3A4 by rucaparib reduces venlafaxine metabolism.
What to do
No dose change is normally needed. Monitor for venlafaxine adverse effects such as nausea, blood pressure elevation and agitation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Venlafaxine?
MediHelp rates the interaction as minor. Rucaparib and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and CYP2D6, and venlafaxine is metabolised mainly by CYP2D6 with a minor CYP3A4 contribution. A modest rise in venlafaxine exposure is possible but is unlikely to be clinically important.
How serious is the interaction between Rucaparib and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Monitor for venlafaxine adverse effects such as nausea, blood pressure elevation and agitation.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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