Drug interactions
Rucaparib + Zolpidem
Severity: Minor
Rucaparib and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise zolpidem concentrations, increasing sedation. The effect is expected to be small.
What this interaction means in plain words
Rucaparib and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated zolpidem metabolism by rucaparib.
What to do
Monitor for excess sedation or next-day drowsiness and reduce the zolpidem dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolpidem
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Zolpidem?
MediHelp rates the interaction as minor. Rucaparib and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise zolpidem concentrations, increasing sedation. The effect is expected to be small.
How serious is the interaction between Rucaparib and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation or next-day drowsiness and reduce the zolpidem dose if it occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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