Drug interactions
Sacubitril / valsartan + Sotalol
Severity: Moderate
Sacubitril / valsartan and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril/valsartan can cause hypotension and hyperkalemia and may reduce renal function. Together with sotalol, which is renally cleared and QT prolonging, this may increase hypotension, bradycardia and arrhythmia risk through potassium or renal changes.
What this interaction means in plain words
Sacubitril / valsartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects, plus angiotensin receptor blockade altering potassium and renal function affecting sotalol clearance.
What to do
Monitor blood pressure, potassium and renal function after starting or changing doses. Adjust the sotalol dose if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sacubitril / valsartan with Sotalol?
MediHelp rates the interaction as moderate. Sacubitril / valsartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sacubitril/valsartan can cause hypotension and hyperkalemia and may reduce renal function. Together with sotalol, which is renally cleared and QT prolonging, this may increase hypotension, bradycardia and arrhythmia risk through potassium or renal changes.
How serious is the interaction between Sacubitril / valsartan and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function after starting or changing doses. Adjust the sotalol dose if renal function worsens.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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