Drug interactions
Sacubitril-valsartan + Succinylcholine
Severity: Moderate
Sacubitril-valsartan and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine releases potassium from muscle and can transiently raise serum potassium, while valsartan reduces potassium excretion. In patients with high baseline potassium or renal impairment, this could add to the risk of hyperkalemia and arrhythmia during anesthesia.
What this interaction means in plain words
Sacubitril-valsartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Additive hyperkalemic effects: succinylcholine-induced potassium efflux plus reduced renal potassium excretion from RAAS inhibition.
What to do
Check potassium before anesthesia in patients on sacubitril-valsartan, particularly with renal impairment, and monitor ECG and potassium perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Succinylcholine
Frequently asked questions
Can I take Sacubitril-valsartan with Succinylcholine?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine releases potassium from muscle and can transiently raise serum potassium, while valsartan reduces potassium excretion. In patients with high baseline potassium or renal impairment, this could add to the risk of hyperkalemia and arrhythmia during anesthesia.
How serious is the interaction between Sacubitril-valsartan and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium before anesthesia in patients on sacubitril-valsartan, particularly with renal impairment, and monitor ECG and potassium perioperatively.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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