Drug interactions
Sacubitril-valsartan + Tacrolimus
Severity: Moderate
Sacubitril-valsartan and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is not a recognized meaningful OATP1B1 inhibitor, so the transporter effect on valsartan is minimal. The more important concern is that both drugs can raise potassium and impair renal function, particularly in transplant recipients.
What this interaction means in plain words
Sacubitril-valsartan and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive hyperkalemia and renal hemodynamic effects from tacrolimus nephrotoxicity and angiotensin receptor blockade.
What to do
Monitor serum potassium, creatinine and blood pressure closely after starting or changing doses, and check tacrolimus trough levels if renal function changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Sacubitril-valsartan with Tacrolimus?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus is not a recognized meaningful OATP1B1 inhibitor, so the transporter effect on valsartan is minimal. The more important concern is that both drugs can raise potassium and impair renal function, particularly in transplant recipients.
How serious is the interaction between Sacubitril-valsartan and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure closely after starting or changing doses, and check tacrolimus trough levels if renal function changes.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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