Drug interactions
Sacubitril-valsartan + Torsemide
Severity: Moderate
Sacubitril-valsartan and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Torsemide is a loop diuretic that lowers potassium and volume, whereas sacubitril-valsartan raises potassium. The combination is standard in heart failure, but volume depletion can cause hypotension and renal impairment, particularly at initiation.
What this interaction means in plain words
Sacubitril-valsartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume and potassium loss combined with RAAS blockade, producing additive hypotension and variable potassium effects.
What to do
Monitor blood pressure, volume status, potassium and creatinine after starting or changing doses, and reduce the diuretic dose if hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Torsemide
Frequently asked questions
Can I take Sacubitril-valsartan with Torsemide?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Torsemide is a loop diuretic that lowers potassium and volume, whereas sacubitril-valsartan raises potassium. The combination is standard in heart failure, but volume depletion can cause hypotension and renal impairment, particularly at initiation.
How serious is the interaction between Sacubitril-valsartan and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, potassium and creatinine after starting or changing doses, and reduce the diuretic dose if hypotension or volume depletion occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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