Drug interactions
Sacubitril-valsartan + Trofinetide
Severity: Moderate
Sacubitril-valsartan and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1 and OATP1B3, which could raise exposure to sacubitril and valsartan, both OATP substrates. This may increase hypotension, hyperkalemia or renal effects.
What this interaction means in plain words
Sacubitril-valsartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake reduces clearance of sacubitril/valsartan components.
What to do
Monitor blood pressure, potassium and renal function, and adjust sacubitril/valsartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Sacubitril-valsartan with Trofinetide?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide may inhibit OATP1B1 and OATP1B3, which could raise exposure to sacubitril and valsartan, both OATP substrates. This may increase hypotension, hyperkalemia or renal effects.
How serious is the interaction between Sacubitril-valsartan and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function, and adjust sacubitril/valsartan dose if hypotension occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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