Drug interactions
Safinamide + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Minor
Safinamide and Sofosbuvir-velpatasvir-voxilaprevir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit intestinal BCRP, which could increase absorption of BCRP substrates including sofosbuvir and voxilaprevir. The expected increase is modest and clinical significance is uncertain.
What this interaction means in plain words
Safinamide and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Safinamide belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Safinamide and its main metabolite may inhibit intestinal BCRP, increasing absorption of BCRP substrates.
What to do
No dose adjustment is expected; monitor for antiviral adverse effects and for increased safinamide effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as minor. Safinamide and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit intestinal BCRP, which could increase absorption of BCRP substrates including sofosbuvir and voxilaprevir. The expected increase is modest and clinical significance is uncertain.
How serious is the interaction between Safinamide and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected; monitor for antiviral adverse effects and for increased safinamide effects.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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