Drug interactions
Safinamide + Tapentadol
Severity: Contraindicated
Safinamide and Tapentadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide is an MAO-B inhibitor, and tapentadol is contraindicated with MAO inhibitors because of the risk of serotonin syndrome and adrenergic crisis. The reaction may be life-threatening.
What this interaction means in plain words
Safinamide and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Safinamide belongs to Central Nervous System; Tapentadol belongs to Musculoskeletal.
Why it happens
MAO inhibition combined with tapentadol's noradrenaline reuptake inhibition and weak serotonergic effects.
What to do
Avoid the combination and choose another analgesic. Observe the labeled washout interval between the drugs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Safinamide with Tapentadol?
MediHelp rates the interaction as contraindicated. Safinamide and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is an MAO-B inhibitor, and tapentadol is contraindicated with MAO inhibitors because of the risk of serotonin syndrome and adrenergic crisis. The reaction may be life-threatening.
How serious is the interaction between Safinamide and Tapentadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another analgesic. Observe the labeled washout interval between the drugs.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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