Drug interactions
Sage + Tramadol
Severity: Minor
Sage and Tramadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage taken as a supplement or tea may have mild sedative effects and could add to tramadol-induced drowsiness. Evidence is scarce, and the effect is likely minor. Some sage species also contain thujone, which can lower seizure threshold in large amounts.
What this interaction means in plain words
Sage and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the mechanism is not well established.
What to do
Counsel the patient to watch for excess drowsiness and avoid concentrated sage products. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Sage with Tramadol?
MediHelp rates the interaction as minor. Sage and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage taken as a supplement or tea may have mild sedative effects and could add to tramadol-induced drowsiness. Evidence is scarce, and the effect is likely minor. Some sage species also contain thujone, which can lower seizure threshold in large amounts.
How serious is the interaction between Sage and Tramadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to watch for excess drowsiness and avoid concentrated sage products. No dose change is usually needed.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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