Drug interactions
Salicylates + Trazodone
Severity: Moderate
Salicylates and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that can impair platelet aggregation, and salicylates can irritate the gastric mucosa and affect platelets. Together they may raise the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Salicylates and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Impaired platelet serotonin uptake combined with salicylate effects on mucosa and platelet function.
What to do
Monitor for signs of bleeding such as black stools or bruising. Consider gastroprotection in high-risk patients, such as the elderly or those with prior ulcers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Salicylates with Trazodone?
MediHelp rates the interaction as moderate. Salicylates and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that can impair platelet aggregation, and salicylates can irritate the gastric mucosa and affect platelets. Together they may raise the risk of gastrointestinal and other bleeding.
How serious is the interaction between Salicylates and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding such as black stools or bruising. Consider gastroprotection in high-risk patients, such as the elderly or those with prior ulcers.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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