Drug interactions
Salmeterol + Tipranavir
Severity: Major
Salmeterol and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, which strongly inhibits CYP3A4 and can raise salmeterol concentrations. This increases the risk of tachycardia, palpitations and QT prolongation.
What this interaction means in plain words
Salmeterol and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Salmeterol belongs to Respiratory; Tipranavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition (via ritonavir-boosted tipranavir) decreases salmeterol metabolism.
What to do
Avoid the combination and choose an alternative bronchodilator. If coadministered, monitor ECG and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Salmeterol with Tipranavir?
MediHelp rates the interaction as major. Salmeterol and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir is given with ritonavir, which strongly inhibits CYP3A4 and can raise salmeterol concentrations. This increases the risk of tachycardia, palpitations and QT prolongation.
How serious is the interaction between Salmeterol and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative bronchodilator. If coadministered, monitor ECG and potassium.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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