Drug interactions
Salsalate + Vortioxetine
Severity: Moderate
Salsalate and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID with weaker antiplatelet effect than aspirin, but it can still contribute to gastrointestinal bleeding. Combined with vortioxetine's effect on platelets, bleeding risk is increased.
What this interaction means in plain words
Salsalate and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of hemostasis: NSAID effects on mucosa and platelets plus reduced platelet serotonin uptake.
What to do
Use the lowest effective salsalate dose for the shortest duration and monitor for gastrointestinal bleeding. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Salsalate with Vortioxetine?
MediHelp rates the interaction as moderate. Salsalate and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID with weaker antiplatelet effect than aspirin, but it can still contribute to gastrointestinal bleeding. Combined with vortioxetine's effect on platelets, bleeding risk is increased.
How serious is the interaction between Salsalate and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective salsalate dose for the shortest duration and monitor for gastrointestinal bleeding. Consider gastroprotection in high-risk patients.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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