Drug interactions
Same + Tramadol
Severity: Moderate
Same and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) has serotonergic activity and tramadol inhibits serotonin reuptake, so combining them may increase the risk of serotonin syndrome. Evidence is limited to reports and theoretical considerations.
What this interaction means in plain words
Same and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects.
What to do
Avoid combining where possible. If used together, monitor for agitation, tremor, diarrhea, hyperthermia and neuromuscular abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Same with Tramadol?
MediHelp rates the interaction as moderate. Same and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) has serotonergic activity and tramadol inhibits serotonin reuptake, so combining them may increase the risk of serotonin syndrome. Evidence is limited to reports and theoretical considerations.
How serious is the interaction between Same and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If used together, monitor for agitation, tremor, diarrhea, hyperthermia and neuromuscular abnormalities.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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